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Need:

 

Stiffness of blood vessels has been established to be a very strong marker of cardiovascular problems and cardiac aging. Evaluation of arterial stiffness requires accurate measurement of changes in arterial dimensions and blood pressure. State of the art methods use specialized ultrasound imaging equipment to perform this measurement. The requirement of expensive technology and extensive technical expertise to use that technology, limits wide spread use of image-based arterial stiffness measurement. There is a need for an affordable, easy to use technology that can be deployed widely with minimal training.

 

Innovation:

 

HTIC has developed ARTerial Stiffness Evaluation for Non-invasive Screening (ARTSENS). It is an image-free technology for non-invasively measuring arterial stiffness in an automated manner. ARTSENS uses custom designed ultrasound probe integrated with proprietary intelligent signal processing to identify arterial anatomy, capture vessel wall dynamics and calculate clinically accepted measures of stiffness. Once the probe is placed over the neck, the device directly yields the stiffness measurement within 30 seconds. A hand-held cardiovascular screening device based on ARTSENS technology is currently under development.

 

Impact:

 

A pilot study conducted in collaboration with MediScan Systems, Chennai on nearly 100 subjects validated the in-vivo measurements made using ARTSENS against a conventional ultrasound imaging system. ARTSENS device was used in a vascular screening camp conducted by Thambiran Heart and Vascular Institute, Chennai to measure arterial stiffness of more than 50 subjects within a period of about 4 hours. These pilot studies demonstrated ability of ARTSENS to measure arterial stiffness under in-vivo settings. The intelligence embedded in the technology allows personnel to use the device with minimal training. 

 

Publications & Patents:

 

  1. J. Joseph, R. Radhakrishnan, S. Kusmakar, A. Thrivikraman, and M. Sivaprakasam, “Technical Validation of ARTSENS–An Image Free Device for Evaluation of Vascular Stiffness,” IEEE Journal of Translational Engineering in Health and Medicine, vol. 3, no. 1, pp. 1–13, Dec. 2015.

  2. A.K. Sahani, J. Joseph, R. Radhakrishnan, M. Sivaprakasam, S. Seshadri “Comparison of measurement of the augmentation index from ARTSENS and eTRACKING,” Biomedical Physics & Engineering Express, vol. 2, no. 1,  pp. 015007, January 2016.

  3. A. K. Sahani, J. Joseph, R. Radhakrishnan, and M. Sivaprakasam, “Automatic Measurement of End-Diastolic Arterial Lumen Diameter in ARTSENS,” ASME Journal of Medical Devices, vol. 9, no. 4, pp. 041002 - 11, 2015, doi:10.1115/1.4030873

  4. A.K. Sahani, M. Shah, J. Joseph, and M. Sivaprakasam, “Carotid and Jugular Classification in ARTSENS,” IEEE Journal of Biomedical and Health Informatics, vol. PP, no. 99, pp. 1–1, 2015, doi: 10.1109/JBHI.2015.2403283.

  5. A. K. Sahani, M. I. Shah, R. Radhakrishnan, J. Joseph and M. Sivaprakasam, "An Imageless Ultrasound Device to Measure Local and Regional Arterial Stiffness," in IEEE Transactions on Biomedical Circuits and Systems, vol. 10, no. 1, pp. 200-208, Feb. 2016, doi: 10.1109/TBCAS.2015.2394468

  6. A. K. Sahani, J. Joseph, and M. Sivaprakasam, “Evaluation of the algorithm for automatic identification of the common carotid artery in ARTSENS,” Physiological Measurement, vol. 35, no. 7, pp. 1299–1317, Jul. 2014.

  7. J. Joseph and V. Jayashankar, “A Virtual Instrument for Automated Measurement of Arterial Compliance,” ASME Journal of Medical Devices, vol. 4, no. 4, p. 045004, 2010.

  8. M.I. Shah, J. Joseph, Aryasree T. and M. Sivaprakasam, “ARTSENS® Mobile: A portable image-free platform for automated evaluation of vascular stiffness,” presented at the 38th Annual International Conference of the IEEE EMBS, Orlando, Florida, 2016.

  9. J. Joseph, P. M. Nabeel, M. I. Shah and M. Sivaprakasam, "Arterial compliance probe for calibration free pulse pressure measurement," 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Benevento, 2016, pp. 1-6. doi: 10.1109/MeMeA.2016.7533810

  10. T. Ganesh, J. Joseph, B. Bhikkaji and M. Sivaprakasam, "Sparse models for determining arterial dynamics," 2015 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), South Brisbane, QLD, 2015, pp. 852-856. doi: 10.1109/ICASSP.2015.7178090

  11. J. Joseph, T. A. Sree, C. Boobalan, M. Sivaprakasam and M. Shah, "Image-free evaluation of carotid artery stiffness using ARTSENS: A repeatability study," 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, 2014, pp. 4799-4802. doi: 10.1109/EMBC.2014.6944697

  12. M. Shah, J. Joseph and M. Sivaprakasam, "Ultrasound signal quality parameterization for image-free evaluation of arterial stiffness," 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, 2014, pp. 2326-2329. doi: 10.1109/EMBC.2014.6944086

  13. M. Shah, J. Joseph and M. Sivaprakasam, "Vascular compliance probe with integrated ECG for image-free evaluation of arterial stiffness," 2014 IEEE International Symposium on Circuits and Systems (ISCAS), Melbourne VIC, 2014, pp. 1384-1387. doi: 10.1109/ISCAS.2014.6865402

  14. A. K. Sahani, J. Joseph, and M. Sivaprakasam, “Automatic measurement of lumen diameter of carotid artery in A-mode ultrasound,” in Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, Osaka, Japan, 2013, pp. 3873-3876.

  15. J. Joseph, E. A. Thomas, M. Sivaprakasam, and S. Suresh, “ARTSENS-An image-free system for noninvasive evaluation of arterial compliance,” in Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, Osaka, Japan,2013, pp. 4054–4057.

  16. A. Chandrasekhar, J. Joseph, and M. Sivaprakasam, “Local Pulse Wave Velocity estimation using Magnetic Plethysmograph,” in Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, Osaka, Japan, 2013, pp. 2287–2290.

  17. A. K. Sahani, J. Joseph, and M. Sivaprakasam, “Automated system for imageless evaluation of arterial compliance,” in Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE, 2012, pp. 227–231.

  18. A. Chandrasekhar, J. Joseph, and M. Sivaprakasam, “A novel magnetic plethysmograph for non-invasive evaluation of arterial compliance,” in Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE, 2012, pp. 1169–1172.

  19. J. Joseph, J. Venkataraman, V. J. Kumar, and S. Suresh, “Non-invasive estimation of arterial compliance,” in Instrumentation and Measurement Technology Conference (I2MTC), 2011 IEEE, 2011, pp. 1–5.

  20. J. Joseph and V. Jayashankar, “Magnetic sensor for non-invasive detection of blood pulse and estimation of arterial compliance,” in Biomedical Engineering and Sciences (IECBES), 2010 IEEE EMBS Conference on, 2010, pp. 170–175.

  21. J. Joseph, V. Jayashankar, and V. J. Kumar, “A PC based system for non-invasive measurement of carotid artery compliance,” in Instrumentation and Measurement Technology Conference,I2MTC’09. IEEE, 2009, pp. 680–685.

  22. J. Joseph and V. Jayashankar, “An improved echo tracking algorithm for arterial distensibility measurements,” in International Conference on Biomedical and Pharmaceutical Engineering, ICBPE’09, 2009, pp. 1–5.

  23. J. Joseph and V. Jayashankar, “Virtual instrument for ultrasound signal processing,” presented at the Ninth National Conference on Technology Trends (NCTT08), Trivandrum, 2008, pp. 242–245.

  24.  J. Joseph and V. Jayashankar, “A virtual instrument for real time in vivo measurement of carotid artery compliance,” in Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE, 2008, pp. 2281–2284.

 

News:

Spot cardio disease years ahead

Indian innovation offers cheap and effective test for heart disease

ARTSENS wins 2015 NI Engineering Impact award.

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